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Dr. Ravi Kumar Kadeppagari

Food Technology

Ravi-Kumar-Photo

Dr. Ravi Kumar Kadeppagari

Professor

Dr. Ravi Kumar Kadeppagari

Email: ravikumar.k@ciirc.jyothyit.ac.in

Ravi Kumar Kadeppagari obtained his education from premier institutes of India, such as the Regional Institute of Education (a constituent of NCERT), Pondicherry Central University and Central Food Technological Research Institute (a constituent of CSIR). He has overseas postdoctoral experience at Northwestern University, Chicago, and LSU Health Sciences Center, New Orleans, USA. He was a recipient of the Young Scientist Research Grant from DST- SERB, New Delhi, and has completed projects from DRDO, DST, VGST and MOFPI. He is an active reviewer for SCI/SCOPUS indexed international journals such as Starch, Current Microbiology, International Journal of Food Science & Technology, Journal of Separation Science, Journal of Chromatography-B, International Journal of Pharmacy & Pharmaceutical Sciences, Phytochemical Analysis, Journal of Electroanalytical Chemistry, FEMS Microbiology Letters, etc.

He has research publications in Scopus and SCI indexed international journals and patents to his credit. He has also supervised doctoral and master students, and is a life member of the Society of Biological Chemists, Association of Microbiologists of India, Indian Science Congress Association, Luminescence Society of India, Institute of Smart Structures & Systems, Association of Food Scientists & Technologists (India), and Society for Biotechnologists (India). He served as the Chairman of the Board of Examiners, Food Technology, Jain University. He qualified Onion Grand Challenge, Ministry of Consumer Affairs, GoI, He received the achievement award for his research contributions from Jain University Trust. He has also received junior and senior research fellowships from CSIR, New Delhi.

  • Teaching: 06 Years
  • Research: 16 Years

Applications of enzymes, enzyme inhibitors, nanomaterials and biosensors in the food, health, biotech and environmental areas.

Society of Biological Chemists, Association of Microbiologists of India, Indian Science Congress Association, Luminescence Society of India, Institute of Smart Structures & Systems, Association of Food Scientists & Technologists (India), and Society for Biotechnologists (India).

Radiation safety, 2005, Northwestern university, Chicago

Journal Publications
  1. Narayanrao KA, Bayineni VK, Sahu CK, Kadeppagari R-K. 2023. Food processing applications of protease activity identified in the methotrexate degrading enzyme of Variovorax paradoxus. Food and Bioproducts Processing. https://doi.org/10.1016/j.fbp.2023.03.007. 139:121-128 (Impact factor 5.1) SCI.
  2. Sahu CK, Bayineni VK, Hampapura JS, Hussain CM,   Kadeppagari R-K. 2023. Characterization of 36-kda dimeric methotrexate-degrading enzyme from variovorax paradoxus, its performance and stability of its cross-linked aggregates. Applied Biochemistry and Microbiology. 59:468–475. (Impact factor 1.06) ISSN 0003-6838, SCI.
  3. Bayineni VK, Kadeppagari RK. 2021. Evaluation of p-Nitrophenyl butyrate based bioautographic method for the identification of lipase inhibitors from the unexplored plant sources. Journal of Plant Biochemistry and  Biotechnology. https://doi.org/10.1007/s13562-021-00686-w.  (Impact factor 1.52). SCI, WoS. 0974-1275, 0971-7811
  4. Dave UC, Kadeppagari RK. 2019. Alanine dehydrogenase and its applications. Critical reviews in Biotechnology. 39: 648-664 (Impact factor 9.06). SCI.  ISSN 0738-8551
  5. Dave UC, Kadeppagari RK. 2018. Purification and characterization of Alanine dehydrogenase from Streptomyces anulatus for its application as a bioreceptor in biosensor. Process Biochemistry. 68: 73-82 (Impact factor 4.88). SCI. ISSN 1359-5113
  6. Bayineni VK, Suresh S , Sharma A, Kadeppagari RK. 2018. Improvement of bilirubin oxidase productivity of Myrothecium verrucaria and studies on the enzyme overproduced by the mutant strain in the solid state fermentation. Journal of General and Applied Microbiology. 64:68-75 (Impact factor 1.35). SCI. online ISSN 1349-8037, Print ISSN 0022-1260
  7. Suresh S, Bayineni VK, Kadeppagari RK. 2017. Glycerol improves the productivity of the lipase inhibitory activity of Streptomyces coelicolor.  International Journal of Pharmacy and Bio Sciences. 8(2): (B) 726-730 (Scopus indexed, SNIP value 0.538). ISSN 0975-6299
  8. Singh G, Bayineni VK, Kadeppagari, RK. 2017. Characterization and kinetics of the lipase inhibitory activity of Streptomyces tendae. International Journal of Pharmacy and Bio Sciences. 8(2): (B) 270-274 (Scopus indexed, SNIP value 0.538). ISSN 0975-6299
  9. Sahu CK, Kadeppagari RK. 2017. Sensory evaluation of kokum drinks by fuzzy logic and a simple method. International Journal of Food Properties. 20: 2608-2615 (Impact factor 3.38). SCI. ISSN online 15322386, print 10942912
  10. Dave UC, Ingale DV, Venkatesh K, Bayineni VK, Kadeppagari RK. 2017. Multiwalled carbonnanotubes enhance the response and sensitivity of the ammonium biosensor based on alanine dehydrogenase. Journal of Electroanalytical Chemistry, 784:102-108 (Impact factor 4.59). SCI. ISSN 1572-6657
  11. Bayineni VK, Kadeppagari RK. 2016. Production of therapeutic methotrexate degrading enzyme and studies on its nanocomplexes with human serum albumin. International Journal of Pharmacy and Pharmaceutical Sciences. 8:41-44 (SCOPUS, SNIP value 0.535). ISSN 0975-1491
  12. Bayineni VK, Venkatesh K, Sahu CK, Kadeppagari RK. 2016. The 46 kDa dimeric protein from Variovorax paradoxus shows faster methotrexate degrading activity in its nanoform compare to the native enzyme.Enzyme and Microbial Technology. 85:38-43 (Impact factor 3.7). SCI. ISSN 0141-0229
  13. Sahu CK , Dave U, Sukrutha S, Bayineni K, Kadeppagari RK. 2016. A Case Study and Perspectives of Human Wisdom on Eco-friendly Food Packaging Materials in India. Biotechnology: An Indian Journal. 12:1-11 (Impact factor 0.89). ISSN 0974-7435
  14. Meghwal M, Banerjee S, Kadeppagari RK. Additives-types, sources, functions and regulations. 2016, Food & Beverage News, July 1-15, 2016. Edited by P.A.Francis, published by Saffron Media Pvt. Ltd., pages-12,16 and 24
  15. Singh G, Suresh S, Bayineni VK,  Kadeppagari RK. 2015. Lipase inhibitors from plants and their medical applications. International Journal of Pharmacy and Pharmaceutical Sciences. 7 (supple 1):1-5 (SCOPUS, SNIP value 0.535). ISSN 0975-1491
  16. Dave UC, Meghwal M, Kadeppagari RK. 2015. Development of enzymatic biosensor for the detection of ammonium. International Journal of Advance Research in Science and Engineering. 4 (sp.issue 1): 1888-1895 (Impact factor 1.2). ISSN 2319-8354 (conference paper)
  17. Bayineni VK, Suresh S , Singh G, Kadeppagari RK. 2014. Development of a bioautographic method for the detection of lipase inhibitors. Biochemical and Biophysical Research Communications. 453:784-786 (Impact factor 3.32). SCI. ISSN 0006-291X
  18. Suresh S, Bayineni VK, Kadeppagari RK. 2014. Strain improvement for the bilirubin oxidase production from Myrothecium verrucaria and studies on the enzyme. International Review of Applied Biotechnology and Biochemistry.  2: 43-50 (conference paper)
  19. Jayaraj S, Suresh S, Kadeppagari RK. 2013. Amylase inhibitors and their biomedical applications. Starch/Starke. 65:535-542 (IMPACT FACTOR 2.68).SCI. ISSN 1521-379X
  20. Kadeppagari RK., Sanchez RL., Foster TP. 2012. HSV-2 inhibits type-I interferon signaling via multiple complementary and compensatory STAT2-associated mechanisms. Virus Research. 167: 273-284 (IMPACT FACTOR 6.28).SCI. ISSN 0168-1702
  21. Herale, R., Sukumaran, U.K. and Kadeppagari, R.K. 2012. Evidence for the improvement of thermostability of the maltogenic α-amylase of Aspergillus niger by negative pressure. Starch/Starke. 64:646-651 (IMPACT FACTOR 2.68). SCI. ISSN 1521-379X
  22. Kadeppagari, RK., Sankar, N. and Thimmapaya, B. 2009. Adenovirus Transforming E1A Protein Induces c-Myc in Quiescent Cells by a Novel Mechanism. Journal of Virology 83:4810-4822 (IMPACT FACTOR 6.54). SCI. ISSN 0022-538X
  23. Sankar, N., Kadeppagari, RK. and Thimmapaya, B. 2009. c-Myc induced aberrant DNA synthesis and activation of DNA damage response in p300 knockdown human cells. Journal of Biological Chemistry, 284(22):15193-15205 (IMPACT FACTOR 5.48). SCI. ISSN 0021-9258
  24. Sankar, N., Baluchamy, S.*, Kadeppagari, RK. *, Singhal, G. *, Weitzman, S. and Thimmapaya, B. 2008. p300 provides a co repressor function by cooperating with YY1 and HDAC3 to repress c-Myc. Oncogene, 27:5717-5728         (IMPACT FACTOR 8.75). SCI. ISSN 0950-9232 (Note* Equally contributing authors)
  25. Singhal, G., Kadeppagari, RK., Sankar, N. and Thimmapaya, B. 2008. Simian virus 40 large T overcomes p300 repression of c-Myc. Virology, 377:227-232 (IMPACT FACTOR 3.51). SCI. ISSN 0042-6822
  26. Kumaresan, N., Sanjay, KR., Venkatesh, KS., Kadeppagari, RK., Vijayalakshmi, G. and Umesh-Kumar, S. 2008. Partially saturated canthaxanthin purified from Aspergillus carbonarius induces apoptosis in prostrate cancer cell line. Applied Microbiology & Biotechnology. 80:467-473 (IMPACT FACTOR 5.56). SCI. ISSN 0175-7598
  27. Ravi–Kumar, K., Venkatesh, K.S. and Umesh-Kumar, S. 2007. The 53 kDa proteolytic product of precursor starch hydrolyzing enzyme of A. niger has Taka-amylase-like activity. Applied Microbiology & Biotechnology. 74:1011-1015. (IMPACT FACTOR 5.56). SCI. ISSN 0175-7598
  28. Ravi–Kumar, , Venkatesh, K.S. and Umesh-Kumar, S. 2004. Evidence that cleavage of the precursor enzyme by autocatalysis caused secretion of multiple amylases by A. niger. FEBS Letters. 557: 239-242 (IMPACT FACTOR 3.86). SCI. ISSN 0014-5793
Paper Presentations in International/National Conferences
  1. Narayanrao KA, Kadeppagari RK. Food applications of protease activity of Variovorax paradoxus (oral presentation). 3 day national seminar on biotechnology for better life: Innovations and advances towards sustainable development organized by Sir M. Visvesvaraya Institute of Technology, Bangalore during 15th to 17th December, 2022.
  2. Kadeppagari RK. Production of cancer therapy related enzyme from Variovorax paradoxus and preparation of its nano CLEAs (poster presentation). International conference at 11th Bengaluru India Nano organized by Dept. of IT, BT and ST, Govt. of Karnataka during 2nd to 4th March, 2020.
  3. Kadeppagari RK. Lipase inhibitory activity isolated from the culture of Streptomyces coelicolor improves the shelf-life of food products. 8th International Food Convention (IFCON 2018) organized by Association of Food Scientists and Technologists of India (AFSTI) at CFTRI, Mysuru during 12th-15th December, 2018.
  4. Suresh S, Kadeppagari RK. Characterization of lipase inhibitory activity of Streptomyces lydicus. Oral presentation at National conference organized by Society of Biotechnologists (India) and Dayananda Sagar University during 15th-16th November, 2018 at Bengaluru.
  5. Bayineni VK, Kadeppagari RK. Bilirubin oxidase nanocomplexes with human serum albumin: Their performance and release kinetics. 85th  annual meeting of Society for Biological Chemists held at CSIR-Central Food Technological Research Institute, Mysuru during November 21-24, 2016.
  6. Dave UC, Bayineni VK, Suresh S, Kadeppagari RK. Nanobiosensor for the detection of ammonia gas. Bangalore India Bio 2016, an international conference held during 9th-11th February, 2016 held by Dept. of IT,BT and ST & Vision group on biotechnology, Govt. of Karnataka.
  7. Dave UC, Venkatesh K, Kadeppagari RK. Development of ammonium biosensor by using the microbial bioreceptor. 56th annual conference of association of microbiologists of India & International symposium on emerging discoveries in microbiology held during 7th-10th December 2015 by Jawaharlal Nehru University, New Delhi and association of microbiologists of India.
  8. Suresh S, Bayineni VK, Singh G, Kadeppagari RK. Screening of Streptomyces spp for lipase inhibitors. 7th annual KSTA national conference organized by Karnataka Science and Technology Academy and oxford college of science during 5th-6th February 2015
  9. Dave UC, Kadeppagari RK. Studies on the alanine dehydrogenase of Bacillus subtilis for the development of ammonia biosensor. 7th annual KSTA national conference organized by Karnataka Science and Technology Academy and oxford college of science during 5th-6th February 2015
  10. Bayineni VK, Suresh S, Kadeppagari RK. Production of carboxypeptidase G2 and preparation of its nanocomplexes with human serum albumin. 83rd annual meeting of Society for Biological Chemists held at KIIT University, Bhubaneswar during December 18-21, 2014 and it was organized by KIIT University, Institute of Lifescience and National Institute of Science Education and Research
  11. Kadeppagari, RK. Improvement of activity and the production of food related fungal metabolites by using multiwall carbon nanotubes. Invited talk at XXII Indian convention of food scientists and technologists (ICFoST XXII) held during December 6-7,2012 at CSIR-CFTRI, Mysore, India
  12. Sukrutha S, Sujatha J, Kadeppagari, RK. Mechanism behind the inhibitor driven enhancement of enzyme production. 81st annual meeting of Society for Biological Chemists held at Science city, Kolkota during November 08-11, 2012 organized by university of Calcutta, Bose institute, Indian Institute of Chemical Biology, IISER-Kolkata etc.
  13. Kadeppagari, RK. Subversion of antiviral responses by Herpes Simplex Virus 2. National Conference on Recent Advances in Chemical and Environmental Sciences (NCRACES-2011) organized by Jain University and Tumkur University during 28-29 December, 2011
  14. Kathyayini H, Rekha M, Kadeppagari, RK. Multiwall Carbon Nanotubes for the improvement of activity and the production of metabolites. 4th Bangalore Nano, 2011, an International Conference organised by Jawaharlal Nehru Center for Advanced Scientific Research (JNCASR) & Dept. of IT, Biotechnology and Science & Technology, Karnataka at Bangalore during December 8-9, 2011
  15. Kadeppagari, RK. Subversion Mechanisms of Type 1 Interferon responses by Herpes Simplex Virus 2. 79th annual meeting of Society for Biological Chemists held at IISc during December 13-15, 2010
  16. Kadeppagari, RK. Baluchamy, S. and Thimmapaya, B. c-Myc induction in quiescent cells by E1A is dependent on E1A binding to p300 and targeting the YY1 binding site of the Myc promoter (oral presentation, SESSION II: Gene Expression). DNA Tumor Viruses Meeting held at the Salk Institute, Lajolla, CA, USA during July 11th-15th, 2006
  17. Kadeppagari, RK. and Thimmapaya, B. c-Myc induction in quiescent cells by E1A is dependent on E1A binding to p300 and targeting the YY1 binding site of the Myc 17th annual scientific poster session “posters and wine” conducted by Robert H. Lurie Medical research center, Chicago, IL, USA on June 28th, 2006
  18. Sankar, N., Kadeppagari, RK. and Thimmapaya, B. Role of p300/CBP in c-Myc regulation, the cell cycle G1-S transition and apoptosis. International symposium on translational research: Apoptosis and Cancer held at Trivandrum, India during 18th– 21st December, 2005
  19. Venkatesh, KS., Ravi-Kumar, K., Karanth, NG. and Umesh-Kumar, S. Production of polygalacturonase by Aspergillus carbonarius: scale up and downstream processing. Association of Food Scientists and Technologists (India) affiliated to the Institute of Food Technologists USA – 15th convention held at Central Food Technological Research Institute, Mysore, India, in 13th-14th December, 2002
  20. . Ravi-Kumar, K. and Umesh-Kumar, S. Protease activity identified in the glucoamylase protein evidenced proteolysis of α-Glucosidase and secretion of multiple amylases by Aspergillus niger. 71st Annual meeting of the Society of Biological Chemists, India held at Punjab agricultural university, Ludhiana, India, in 14th-16th November, 2002
Patents
  1. Eugene Raj A., Venkatesh K.S., Ravi-Kumar K., Umesh Kumar S., Misra M.C., Ghildyal N.P., Karanth N.G. and Gowthaman M.K. An improved process for the production of pectinase enzyme from Aspergillus carbonarius. patent no. IN197187.
Grants/Funded Projects/ Consultancy
  • Therapeutic enzymes from microbial sources: Production improvement and Studies on their human serum albumin nanocomplexes, 2012-2015, 22.7 Lakhs, SERB, New Delhi
  • Development of nano-biosensor for the ammonia detection for the use in micro air vehicles, 2014-2016, 37.72 Lakhs, Ministry of defence, New Delhi
  • Creation of infrastructure facilities for M.Tech.(Food Technology) course under HRD scheme, 2014-16, 75 lakhs, MOFPI, New Delhi
  • Improvement of thermostability and functionality of cancer therapy related enzyme isolated from Variovorax paradoxus by using nano approaches,2018, 20 lakhs, VGST, Bengaluru
  • Development of Edible film from onion peel, 2023, 1 lakh, Onion Grand Challenge, Ministry of Consumer Affairs, GOI, New Delhi.
Achievements and awards
  1. 2023,Onion grand challenge, Ministry of Consumer Affairs, GoI
  2. 2015,Award and medal for achievement in research– by Jain            University Trust, Bengaluru
  3. 2012, DST-SERB- Young Scientist Grant
  4. 2002-2004,Awarded Senior Research fellowship by the CFTRI after the recommendation of CSIR evaluation committee and successfully completing the junior research fellowship
  5. 2002,First Prize in Biotechnology – Association of Food Scientists and Technologists (India) affiliated to the Institute of Food Technologists USA – 15th convention held at Central Food Technological Research Institute, Mysore, in December, 2002. Title: Production of polygalacturonase by Aspergillus carbonarius: scale up and downstream processing
  6. 2002,Best Poster Award – Meeting of the Society of Biological Chemists, India held at Punjab agricultural university, Ludhiana in November, 2002. Title: Protease activity identified in the glucoamylase protein evidenced proteolysis of α-Glucosidase and secretion of multiple amylases by Aspergillus niger
  7. 2000,Awarded Junior Research fellowship after qualifying the prestigious all India level national eligibility test (NET) conducted by Council of Scientific and Industrial Research & University Grants Commission, New Delhi to identify strongly motivated young post graduates towards research
  8. 2000,Qualified national level Graduate Aptitude Test in Engineering (GATE) under Life sciences, conducted by Indian Institute of Technology, Kharagpur
  9. 1999, Summer fellowship- Department of Applied Botany and Biotechnology, University of Mysore, Mysore
Resource Person for workshops / FDPs
  • Kadeppagari, RK. Improvement of activity and the production of food related fungal metabolites by using multiwall carbon nanotubes. Invited talk at XXII Indian convention of food scientists and technologists (ICFoST XXII) held during December 6-7,2012 at CSIR-CFTRI, Mysore, India

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